Management of the breeding environment for senescence mice and their background data

新美 君枝

研究基盤開発部門 動物資源開発支援ユニット


Mice used in aging research should be kept without pathogenic contamination over a long period. Thus, specific pathogen-free (SPF) mice are mainly used for examinations. And it is desirable that those mice are provided for studies with the background data.

Recently, there has been an increasing interest in germ-free (GF) mice among researchers. It is known that GF mice can live longer than SPF mice, which suggests a possibility of GF mice as a model for aging research. All GF mice are introduced by hysterectomy method and are kept in vinyl isolators or the new cage system, a sealed positive pressure individual ventilated cage system.

This study aims to establish the operational method of the new cage system for GF mice and develop a behavioral monitoring system under GF environment. The basic behaviors such as home cage activity and intakes of water and food taken from the behavioral monitoring system are valuable background data for aging research. By preparing and providing those research support systems, we can contribute to aging research and maximize the return to society.