Translation analysis of neuronal aging in the brain of neurodegenerative diseases

Motomasa Tanaka

Center for Brain Science (CBS)
Laboratory for Protein Conformation Diseases
Team Leader


Cellular aging is involved in a variety of neurodegenerative diseases including Alzheimer’s disease and Parkinson’s disease. Previous studies suggest that such neurodegenerative disorders are at least partly caused by aberrant mRNA translation. However, it remains unclear how dysregulation of mRNA translation is linked to cellular aging and neurodegeneration. Here we will establish molecular profiling techniques that allow us to comprehensively analyze mRNA translation in the brain of aging and neurodegenerative disease model mice. This study will provide key clues for understanding the molecular basis of cellular aging and its related human brain disorders.